Optimization in Drug Discovery: In Vitro Methods (Methods in Pharmacology and Toxicology)

Thoroughly revised and up-to-date, Optimization in Drug Discovery: In Vitro equipment, moment Edition offers a large spectrum of in vitro assays together with formula, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions through evaluate of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology sequence, chapters contain introductions to their respective issues, lists of the mandatory fabrics and reagents, step by step, quite simply reproducible protocols, and pointers on troubleshooting and keeping off recognized pitfalls. professional authors have constructed and applied those in vitro assays to accomplish “drug-like” features as well as efficacy houses and strong safeguard profiles of drug candidates.

Comprehensive and up to date, Optimization in Drug Discovery: In Vitro tools, moment Edition goals to lead researchers down the tough route to winning drug discovery and development.

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